A role of C. albicans Rpn4 in regulating antifungal drug susceptibility (#36)
Ka Pui Sharon Yau
1
,
Harshini Weerasinghe
1
,
Barbara Koch
1
,
Traude Beilharz
1
,
Ana Traven
1
- Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia
Publish consent withheld
- Hitchcock, C. A., Dickinson, K., Brown, S. B., Evans, E. G. & Adams, D. J. 1990. Interaction of azole antifungal antibiotics with cytochrome P-450-dependent 14 alpha-sterol demethylase purified from Candida albicans. Biochem J, 266, 475-80. Resistance and tolerance to azoles
- Whaley SG, Berkow EL, Rybak JM, Nishimoto AT, Barker KS, Rogers PD. Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species. Front Microbiol. 2017 Jan 12;7:2173. doi: 10.3389/fmicb.2016.02173
- Rosenberg, A., Ene, I. V., Bibi, M., Zakin, S., Segal, E. S., Ziv, N., Dahan, A. M., Colombo, A. L., Bennett, R. J. & Berman, J. 2018. Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia. Nat Commun, 9, 2470.
- Xie, Y. & Varshavsky, A. 2001. RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuit. Proc Natl Acad Sci U S A, 98, 3056-61.