Friday, 19th February Lorne Infection and Immunity 2021

LATEST ADVANCEMENTS IN IMMUNE-RECEPTOR PROFILING AND SINGLE CELL MRNA SEQUENCING

Speaker: Bryan Bell, PhD

The immune system is composed of a complex hierarchy of cell types that protect the organism against disease and maintain homeostasis. Understanding the heterogeneity of the full array of cells involved, such as T cell and B cell lymphocytes, is the key to understanding the immune system. Takara Bio's next-generation sequencing (NGS) technologies have revolutionized our understanding of immunological phenomena and human disease by enabling analyses of gene expression, gene regulation, and immune receptor information with unprecedented sensitivity. With the results of our best-in-class bulk profiling kits and our innovative single-cell chemistry, scientists can gain new insights into the immune repertoire. Here, we will present our latest advancements in immune-receptor profiling and single cell mRNA sequencing.

Be sure to view the e-Poster Hall throughout the conference.  All e-Poster and Science Bite presenters will be online to answer any questions during both Poster Sessions.

• Organelle wars and the enemy within - Matthew J Sweet
• ­Arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages at the mitochondria - Jennifer K Dowling
• Z-DNA-binding protein-1 regulates necroptosis-mediated skin inflammation - Snehlata Kumari
• Histone deacetylase 7 coordinates innate immune defence by promoting phagocytosis, NADPH oxidase-dependent reactive oxygen species production and bacterial clearance - Kaustav Das Gupta
• Succination inactivates gasdermin D and blocks pyroptosis - Kate Fitzgerald

• My career path and advocacy - Akiko Iwasaki

• Bringing metagenomics to the patient bedside to combat the emerging global health threat: the rise of invasive fungal infections - Wieland Meyer
• TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis - Hamsa Puthalakath
• Genomic Analysis of Fungal Morphogenesis and Interaction with Host Immune Cells - Leah Cowan

• Creating Vaccines at Pandemic Speed: Molecular clamp stabilized subunit vaccine - Keith Chappell
• Pre-empting danger to protect against gut infections - Gabrielle Belz

• Immunomodulatory effects of neonatal Bacillus Calmette–Guérin vaccination on responses to unrelated pathogens - Nicole L Messina
• Immune system development varies according to age, location, and anemia in African children - Danika L Hill
• Novel virus-like particle encoding the circumsporozoite protein is an immunogenic malaria vaccine in mice - Liriye Kurtovic

• Dendritic cell paralysis contributes to immunosuppression and secondary infections long after severe infection or trauma; investigation on the mechanisms, diagnostic markers and restorative therapies - Mitra Ashayeripanah
• Single cell analysis of αβ versus γδ T cell development - Seungyoul Oh
• Interferon ε as a novel regulator of intestinal homeostasis - Eveline D de Geus

• Immune features associated with COVID-19 - Tracy Hussell
• HIV-1 has paved the way in the battle against SARS-CoV-2 - Marit van Gils

Closing Remarks by Heidi Drummer